Answer:
Might be a lack of sleep, try taking care of your self and take medicine by doctor.
Explanation:
Answer:
Okay
Explanation:
Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. It also is the target for camptothecin-based anticancer drugs that act by increasing levels of topoisomerase I-mediated DNA scission. Evidence suggests that cleavage events most likely to generate permanent genomic damage are those that occur ahead of DNA tracking systems. Therefore, it is important to characterize the ability of topoisomerase I to cleave positively supercoiled DNA. Results confirm that the human enzyme maintains higher levels of cleavage with positively as opposed to negatively supercoiled substrates in the absence or presence of anticancer drugs. Enhanced drug efficacy on positively supercoiled DNA is due primarily to an increase in baseline levels of cleavage. Sites of topoisomerase I-mediated DNA cleavage do not appear to be affected by supercoil geometry. However, rates of ligation are slower with positively supercoiled substrates. Finally, intercalators enhance topoisomerase I-mediated cleavage of negatively supercoiled substrates but not positively supercoiled or linear DNA. We suggest that these compounds act by altering the perceived topological state of the double helix, making underwound DNA appear to be overwound to the enzyme, and propose that these compounds be referred to as ‘topological poisons of topoisomerase I’
Answer:
The Diathesis-Stress Model explains that psychological disorders derive from the combination of a predisposition to vulnerability or diathesis, as an innate factor, together with experiences of stress as an acquired factor. Therefore, innate factors and acquired factors are needed to develop certain disorder.
Explanation:
From the perspective of the diathesis-stress model, a disorder is the result of the interaction between a genetic predisposition or vulnerability (diathesis), with external factors or personal experiences (stress). This model is used to explain the development of mental disorders with a clear genetic basis, such as schizophrenia, bipolar disorder, etc. The appearance of the disorder will depend on the combination of both factors. The more genetic predisposition you are, the more likely you are to develop these low-stress diseases. And on the contrary, a low predisposition protects us from suffering a mental disorder, even if different stressors occur in our life.
