Answer:
If something is at rest it will stay at rest UNTIL a force acts upon it same thing if it is moving it will go in a straight line unless an outside force is acted upon it
This law is also known as the law of inertia.
Long-term potentiation (LTP) is considered a cellular correlate of learning and memory. The presence of G protein-activated inwardly rectifying K(+) (GIRK) channels near excitatory synapses on dendritic spines suggests their possible involvement in synaptic plasticity. However, whether activity-dependent regulation of channels affects excitatory synaptic plasticity is unknown. In a companion article we have reported activity-dependent regulation of GIRK channel density in cultured hippocampal neurons that requires activity oF receptors (NMDAR) and protein phosphatase-1 (PP1) and takes place within 15 min. In this study, we performed whole-cell recordings of cultured hippocampal neurons and found that NMDAR activation increases basal GIRK current and GIRK channel activation mediated by adenosine A(1) receptors, but not GABA(B) receptors. Given the similar involvement of NMDARs, adenosine receptors, and PP1 in depotentiation of LTP caused by low-frequency stimulation that immediately follows LTP-inducing high-frequency stimulation, we wondered whether NMDAR-induced increase in GIRK channel surface density and current may contribute to the molecular mechanisms underlying this specific depotentiation. Remarkably, GIRK2 null mutation or GIRK channel blockade abolishes depotentiation of LTP, demonstrating that GIRK channels are critical for depotentiation, one form of excitatory synaptic plasticity.
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Answer:
Mendicant, member of any of several Roman Catholic religious orders who assumes a vow of poverty and supports himself or herself by work and charitable contributions. The mendicant orders surviving today are the four recognized by the Second Council of Lyon (1274): Dominicans, Franciscans, Augustinians (Augustinian Hermits), and Carmelites, as well as Trinitarians, Mercedarians, Servites, Minims, Hospitallers of St. John of God, and the Teutonic Order.
Explanation: Britannica
