Answer:
The answer is reciprocal chromosomal translocation
Explanation:
The Philadelphia chromosome (Ph) is the truncated chromosome 22 generated by the reciprocal translocation t(9;22)(q34;q11) and was first identified in 1960 in a patient with CML [3]. Translocation of the proto-oncogene tyrosine-protein kinase (ABL1) gene located on chromosome 9 to the breakpoint cluster region (BCR) gene located on chromosome 22 results in a BCR-ABL1 fusion gene on the Ph [4, 5]. Three BCR-ABL1 fusion gene hybrids encode BCR-ABL1 protein isoforms p210, p190, and p230, which have persistently enhanced tyrosine kinase (TK) activity. These aberrantly activated kinases disturb downstream signaling pathways, causing enhanced proliferation, differentiation arrest, and resistance to cell death [6, 7]. Tyrosine kinase inhibitors (TKIs) targeting the BCR-ABL1 protein are the most successful targeted therapy for Ph-positive leukemia.
D. Decomposers return everything back to the environment
Most DNA is found in the cell nucleus
Answer:
Multiple Sclerosis is an inflammatory disease in which myelin sheath of nerve cells of brain and spinal cord are damaged.
Explanation:
Cause:- (Exact cause of inflammation is not known)
- But damage is caused due to attack by autoimmune cells or antibodies against myelin sheath.
Types of tissues attack:-
- Oligodendrocytes and myelin sheath is damaged and stripped away from axon and the process is known as demyelination.
- Myelin sheaths are made up of fatty tissues and help in transmission of electric impulse.
Result of immune system attack:-
- Damaged myelin sheath stop forming whIte matter of central nervous system.
- Hence disrupt coordinating communication between different brain regions.
Signs and symptoms:- vary from person to person
- Diminished eyesight.
- Disrupt motor coordination.
- Weak sensory perception.
- Fatigue and dizziness.
- Speech disorder.
- Muscle weakness and spasticity.
- Difficulty in urination and stool.
Diagnosis and treatment:-
- Diagnosis include MRI T2 findings and cerebrospinal fluid specific oligoclonal bands.
#SPJ2
