The Second Battle of Bull Run (Second Manassas).
The themes that played a major role in changing the world between 1450 and 1750 was that plants were being spread together with animals and diseases between the Americas and the rest of the world; mainly Europe. Especially famous are cases where European contact wiped out whole villages and tribes of native American people because they were unable to cope with the bacteria and viruses.
Taft-Hartley Act intended to limit the power of labor unions and their leaders in terms of negotiating salaries and exercising the right to strike. Many of these statutes are still in place.