Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
Learn more about breast cancer here : brainly.com/question/6747562
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The genetics of red hair appear to be associated with the melanocortin-1 receptor (MC1R), which is found on chromosome 16. Eighty percent of redheads have an MC1R gene variant.
I cannot find this source for this I'm sorry. I meant to add it but I lost the site
What this student is doing is collecting data. So, he wants to check how many life forms there are in the waters nearby. In order to do so, he has to take a sample, and look at it through a microscope so as to determine the number. So, he collected a sample which is his data. He is not drawing conclusions yet, but rather counting these organisms. He is not making a peer review - his peers aren't even mentioned here. He is not forming a hypothesis because he is just counting at this point.
If a fabric has been tested for pilling, the grade can be located on the fabric sample and online. ISO-12945-2: 2000 Martindale Method with 415g loading mass
Some plants also have large leaves to soak up nutrients and water, very helpful in this biome since it rains a lot. - Having some needles cased in wax, withstand cold temperatures and losing water from their leaves. - Having thin bark and shallow roots enables trees to withstand fire.
