The British lost immense amount of money for becoming victorious in the French and Indian War. They needed to get the money back to strengthen their economy. For this purpose, they taxed the people of the colonies unduly. This resulted in the colonists becoming angry and revolting against the British. This was the negative effect of the French and Indian War. I hope the answer has come to your help.
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If you're referring to the Revolutionary War, Native Americans chose to either fight on the side of the British, or on the side of the colonists. At the same time, Native Americans were facing challenges defending their own homeland against the imperial powers.
The death toll was substantially higher for both civilians & military forces.