Which one all of the or what
<span>Lafora disease is the most severe teenage-onset progressive epilepsy, a unique form of glycogenosis with perikaryal accumulation of an abnormal form of glycogen, and a neurodegenerative disorder exhibiting an unusual generalized organellar disintegration. The disease is caused by mutations of the EPM2A gene, which encodes two isoforms of the laforin protein tyrosine phosphatase, having alternate carboxyl termini, one localized in the cytoplasm (endoplasmic reticulum) and the other in the nucleus. To date, all documented disease mutations, including the knockout mouse model deletion, have been in the segment of the protein common to both isoforms. It is therefore not known whether dysfunction of the cytoplasmic, nuclear, or both isoforms leads to the disease. In the present work, we identify six novel mutations, one of which, c.950insT (Q319fs), is the first mutation specific to the cytoplasmic laforin isoform, implicating this isoform in disease pathogenesis. To confirm this mutation's deleterious effect on laforin, we studied the resultant protein's subcellular localization and function and show a drastic reduction in its phosphatase activity, despite maintenance of its location at the endoplasmic reticulum.
I got my information from </span>https://www.ncbi.nlm.nih.gov/pubmed/14722920
Answer:
Your body sends a message to the lungs and tell the lungs to breathe in more oxygen so that the oxygenated blood can travel to the muscles oxygenating the cells within that specific muscle and giving them energy to use the sugars stored in fat or food from digestion. The heart beats faster so that the cells supply keeps up and continues to beat fast for that specific diration of time until your breathing slows down and it no longer needs to work as fast to supply the muscles with as much blood.
Answer:
1) Oceanic-oceanic divergence
2) Continental- continetal convergence
3) Oceanic-oceanic convergence
Explanation:
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