The shape of an enzyme is very important because it has a direct effect on how it catalyzes a reaction. An enzyme's shape is determined by the sequence of amino acids in its structure, and the bonds which form between the atoms of those molecules.
Direct effects, as the name suggests, while not manipulated or communicated by a third party, deal with the direct influence of one entity on another. Indirect effects can be described as the influence, mediated or passed on by a third, of one organism or species on another.
Different enzymes have specific active sites which can only catalyze one <span>substrate. Enzyme-substrate complexes are produced only when the substrate fits into the active site :)</span>
The second question has the answer of A