The answer is all of the above
The substrate and the active site both need to fit together perfectly in order for the enzyme to work properly. If their shape is changed, typically through heat or a change in pH, the enzyme will not work.
Adaptation is a phenomenon that is about adjusting certain features to environmental conditions. Ie. birds are adapted to flight as they possess wings, very efficient lungs etc. or tropical plants are adapted to high temperature and humidity as they modified their photosynthesis process. but if some creature is adapted to the specific habitat or conditions, it is hard for it to manage in another habitat/different conditions. ie. birds are fast in the air but on the ground they are quite weak and prone to predators' attacks.
Answer: hi, im here to help :3
so, you can either use plants, use pesticides and fertilizers less often or the one thing i know is consider a rain barrel.