Tricyclic antidepressant (TCAs) class is most closely linked with anticholinergic side effects.
Amitriptyline, amoxapine, clomipramine and protriptyline are Tricyclic antidepressants (TCAs) that are used to treat chronic pain. Amitriptyline and nortriptyline among these medications provide the most reassuring safety information during pregnancy and breastfeeding.
In vitro and in vivo, TCAs are powerful inhibitors of norepinephrine and/or serotonin reuptake. In addition, several TCAs are known to block sodium, calcium, alpha-1 adrenoceptors, histamine (H1) receptors, and muscarinic cholinergic receptors. Thought to be responsible for their unfavourable anticholinergic, antihistaminergic, and cardiotoxic side effects rather than their antidepressant effects, these neurotransmitter receptor actions.
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Explanation:
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For a 15-month-old toddler, who is being treated for acute lymphoid leukemia, there are vaccines contraindicated, especially if the child undergoing chemotherapy. For example, live vaccines such as varicella, oral polio, measles-mumps-rubella (MMR) and bacillus Calmette-Guérin (BCG) should not be given to children under chemo. Although, inactive vaccines may be fine but active vaccines should not be administered.
Answer:
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Explanation:
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Ans: Physician-Assisted Dying (PAD) is defined as a physician providing, at the patient's request, a prescription for a lethal dose of medication that the patient can self-administer by ingestion, with the explicit intention of ending life.
