There are many things that our first president did before his presidency. He even assisted with the creation of our great Constitution. However, the most important thing was when he agreed to lead this great country. Take a look at this website about George Washington and the Indians to find out information on your topic.
http://nativeamericannetroots.net/diary/1077
Depending on what you mean, it changed when the north saw that slavery was not just, and started goin on the attack on it. Which lead to the whole civil war of confederates vs the union
The answer is A) General Anthony Wayne's victory at the Battle of Fallen timbers. That had a big impact, and changed things up.
~Deceptiøn
I say C. because the entire paragraph is talking about political power.