A group of Chinese women with PCOS who were receiving treatment saw several metabolic and hormonal imbalances improve after taking BBR. The primary consequences may be connected to the modifications in body composition in obesity and dyslipidemia. For the evaluation of the possible beneficial metabolic effects of BBR in women with PCOS, additional controlled trials are required.
PCOS:
- Objective: Insulin resistance is a common metabolic and reproductive condition called polycystic ovarian syndrome (PCOS) (IR). A quinoline derivative alkaloid known as berberine (BBR) has been utilized as an insulin sensitizer and is isolated from Chinese medicinal herbs. There may be a therapeutic benefit for PCOS from BBR. The purpose of this study was to compare the effects of BBR and metformin (MET) on the metabolic characteristics of PCOS-affected women.
- Design and methods: Ninety nine PCOS and IR patients were randomly assigned to one of three therapy groups: BBR+ compound cyproterone acetate (CPA;
), MET
CPA
, and placebo CPA 
for 
months. Before and after the treatment period, metabolic and hormonal measures as well as the clinical characteristics of the women were evaluated. - Results: Reduced waist circumference, waist-to-hip ratio (WHR;P<
), total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDLC; P<
), as well as increased levels of high-density lipoprotein cholesterol (HDLC) and sex hormone-binding globulin (SHBG; P<) were all observed following treatment with BBR as compared to MET. Similarly, BBR treatment decreased WHR, fasting plasma glucose, fasting insulin, homeostasis model evaluation for IR, area under the insulin curve, TC, LDLC, and TG (P<), while increasing HDLC and SHBG (P<) as compared to placebo.
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Answer:
Nitrogen is removed from the atmosphere mainly by nitrogen-fixing bacteria in the soil and oceans (blue-green algae).
Explanation:
Nitrogen is removed from the atmosphere mainly by nitrogen-fixing bacteria in the soil and oceans (blue-green algae).
I think the correct answer from the choices listed above is the last option. Some gaming marketers focus on <span>people in their 20s </span>of the population. Because they encourage these group to chill at times or rest after all the work done in a day. Hope this answers the question.
Answer:
Mutations of enzymes involved in nucleotide excision repair.
Explanation:
- Xeroderma pigmentosum is a genetic disorder and the person suffering from this disorder is sensitive to ultraviolet light due to the disability of the enzymes involved in nucleotide excision repair which prevents DNA damage caused by ultraviolet light.
- Thus, the individuals are sensitive to the exposure of UV and suffer severe problems when exposed to sunlight.
- The major cause of the disorder is the inability to repair DNA damage caused by exposure to sunlight due to the mutation in an enzyme involved in nucleotide excision repair.
- Nucleotide excision repair is a DNA repair process that can excise out single-stranded DNA that is damaged by UV.
- UV exposure leads to the addition of bulky adducts in the DNA known as thymine dimers. The enzymes of NER are involved in the removal of these adducts by excising out a segment of DNA that contains such lesions.
- However, in the case of XP, the mutations make this repair system non-functional or partially functional and thus, the individual becomes highly sensitive to UV exposure.
