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Some of the factors are:
<span>-Moderate climate.
-central geography,
-ease of transportation,
-highways,
-railroads,
-location near a large body of water
</span>Large cities tend to develop far from cities that had either too hot or too cold temperature. It also must be easily accessible by other regions and provide the people with necessary resources that help them sustain their living (such as water, food crops, woods, etc)
The t<u>unica media</u> is composed of an endothelial layer that is continuous with the endocardium of the heart.
<h3>What is tunica media?</h3>
Collagen, elastin, and smooth muscle cells make up tunica media. It is located halfway between the tunica externa and the tunica intima. The transverse arrangement of its strands and color make the middle coat (tunica medium) distinct from the inner (tunica intima). It not only supports the vessel but also alters the vessel's width to control blood pressure and flow.
Elastic fibers make up the majority of the tunica media in bigger vessels. The number of elastic fibers reduces as arteries get smaller, whereas the number of smooth muscle fibers grows. The strongest of the three layers is the tunica adventitia, which is the top layer. Elastic and collagenous fibers make up its structure.
Learn more about tunica media here:
brainly.com/question/15395381
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