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Answer: All plasma membrane surfaces are hydrophilic. In comparison, because of the fatty acid tails, the interior of the membrane between its two surfaces is a hydrophobic or nonpolar region. The main fabric of the membrane is composed of two layers of phospholipid molecules. The hydrophilic or "water-loving" areas of these molecules are in contact with the aqueous fluid both inside and outside the cell. Hydrophobic, or water-hating molecules, tend to be non-polar.
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