The correct answer is "The introduction of Islam into Central Asia."
Nowadays Islam is the most practiced religion in Central Asia, this happened because of the of the Mongol invasion of Central Asia, this happened during the 13th century and changed the place completely.
Yet it was the Louisiana Purchase of 1803 that brought the issue of Indian sovereignty into question and initiated an era of court decisions removing many tribes from their established lands east of the Mississippi River. Therefore, 1803–1840 is considered the era of removal.
This quote can be understood as Jefferson's dislike for government with a strong power- a government that wants to control and regulate too much can harm the people rather than be beneficial for them. For this reason the concept of limited government was developed-a government that does not have too much power
