The United States first began developing nuclear weapons in 1939, during World War II, under the order of President Franklin Roosevelt. Motivation was the fear that US was engaged in a race with Nazi Germany to develop nuclear weapon. This project is best known as Manhattan Project.
The Great Depression was a severe worldwide economic depression that took place mostly during the 1930s, beginning in the United States. The timing of the Great Depression varied across nations; in most countries it started in 1929 and lasted until the late-1930s
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