The correct answer to this open question is the following.
I think that what happened to the lost colonists was the following.
First, I have to say that we are talking about the lost colony of Roanoke, North Carolina, in colonial American times.
In 1587, the first group of English explorers or settlers arrived in the North American territory. More specifically, at the Island of Roanoke, modern-day North Carolina. Those 115 English colonists named John White as their governor. There, White had to return to England to get more food and supplies. The thing was that he couldn't immediately get back to Roanoke because the British war against Spain demanded the use of all the ships.
Three years later, in 1590, White finally returned to Roanoke but sadly, nobody was there. They literally "disappeared." That is still a mystery today.
I think the colonists tried to survive the harsh environment and different climate conditions and had to move to find food. They could intermingle with some Native American Indians: Some friendly, that accepted to help them. Some not, and probably they killed the colonists.
