Answer:
1 monosomy
2 trisomy
3 Down syndrome
4 Turner syndrome
5 non-disjunction
6 metaphase
7 twenty-two
8 largest (chromosome 1)
9 smallest (chromosome 22)
10 karyotype
Explanation:
Non-disjunction during meiosis I or II occur when homologous chromosomes or sister chromatids refuse to separate. This makes the resulting gametes to have too many or too few chromosome numbers in their genomes.
A gamete with too few chromosome number that participates in fertilization with a normal gamete will result in a zygote with abnormally less chromosome number. This situation is referred to as monosomy. Whereas, the fusion of a gamete with too many chromosome number with a normal gamete will result in a zygote with too many chromosome, a situation known as trisomy.
The manifestation of monosomy and trisomy in humans results in Turner and Down syndromes respectively.
Humans have 23 pairs of chromosomes out of which a pair determines maleness or femaleness - the sex chromosome. Other chromosomes are referred to as autosomes. Hence, there are 22 autosome pairs and 1 pair of sex chromosome.
Chromosomes are studied by karyotyping, a process that involves photographing chromosomes at the metaphase stage of the cell cycle, cutting them out, and then arranging them in decreasing order of size.
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