Question

Scientists looking for a repressor of the androgen receptor (AR)-mediated transcription gene discovered a protein, Ankrd1. ARs were observed to bind to Ankrd1 and, in cells where Ankrd1 was over-expressed, AR-mediated transcription was inhibited. The scientists also detected lower levels of ARs when Ankrd1 was overexpressed using chromatin immunoprecipitation (ChIP) and Ankrd1 was not detected by ChIP.Based on these observations, which of the following conclusions would the scientists most likely draw?
A. Ankrd1 is binding to ARs and preventing ARs from binding to the promoter, which inhibits mRNA transcription
B. Ankrd1 is binding to the promoter and blocking ARS from binding, which prevents transcription of AR- mediated genes.
C. Ankrd1 is binding to multiple sites and causing DNA to loop, preventing ARS from binding and activating gene transcription
D. Ankrd 1 is binding to chromatin, recruiting proteins that remove acetyl groups, and silencing transcription of that region of DNA.

Answer 1

Answer: A- Ankrd1 is binding to ARs and preventing ARs from binding to the promoter, which inhibits mRNA transcription.

Explanation: