This disease is more common in African Americans and
females. Contractures of the fingers are classic for systemic lupus
erythematosus. The butterfly rash on the face is common, occurring in up to 40%
of affected individuals. Joint involvement is common. Pain is generally more
profound in the morning.
When light traveling in a vacuum enters a new transparent medium, such as air, water, or glass, the speed is reduced in proportion to the refractive index of the new material. As the slider is translated to the right, the refractive index increases and the speed of light subsequently decreases.
Answer:
A mutation in Ras protein which will cause hyperactivity will eventually lead to cancer.
Explanation:
Ras protein was first discovered in Rous sarcoma virus (RSV) and it is a proto-oncogene product. In normal conditions, it plays an important role in cellular signalling but in case of gain of function/hyperactivity it gets converted into cellular oncogene. In several types of cancers a point mutation has been reported in Ras protein.
Just like G protein, it is also a GTPase switch protein but unlike G protein which is trimeric, it is monomeric. In the plasma membrane, it is attached with the help of lipids like prenyl or palmitoyl groups. During signal transduction pathway when it gets activated, it downstream activates MAPK pathway and causes gene expression but when it gets hyperactivated it causes over expression of genes leading to cancer.