Each layer contains the square of the layer number.
<span>So,
Let's figure out :
1 squared = 1 </span>
<span>2 squared = 4 </span>
<span>3 squared = 9 </span>
<span>4 squared = 16 </span>
<span>5 squared = 25
</span>6 squared = 36
<span>Hence,
The total number of oranges in the pile = 1+4+9+16+25+36
= 91 oranges
</span><span>
D. 91</span>
Answer:
1. It was a control variable
2. Type of insulation
3. Temperature
4. Plastic lids <em>or </em>Water <em>or </em>Half Full <em>or </em>Direct Sunlight
Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
Learn more about breast cancer here : brainly.com/question/6747562
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Answer:
Ruminants, cecal fermenters, and monogastrics have different abilities for digesting forages because of their digestive physiology and their diet. ... The cecal fermenters have larger intestine and ceca than monogastrics that allow them to have a large fermentation capacity as well as ruminants.
Explanation:
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Answer:
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