D is your answer. it gives a more specific answer than the other choices, plus it is true. Slavery has been around since Jesus time, so that's way longer than the 1500s
It adopted a policy of isolationism
I would say the best three answers for this question are <span>B. A high cost to society for education C. An increase in the general risk of getting an STD/STI D. Economic costs. Generally, STIs/STDs do not have a positive affect on anything</span>