The health care provider would likely add A diuretic to the regimen to better control the client's hypertension. 
When losartan therapy is started, maximal effects on blood pressure usually occur within 3 to 6 weeks. If losartan alone does not control blood pressure, a low dose of a diuretic may be added. A combination product of losartan and hydrochlorothiazide is available.
        
             
        
        
        
Mutations are caused by changes in nucleotide bases. these altered base formed different amino acid depending upon nucleotide base sequence that code specific amino acid. ... even though some mutations, can have a more effect on amino acid coding, which can affect what kind of proteins are produced.
 
        
             
        
        
        
Answer:
Cancer is caused by changes to certain genes that alter the way our cells function. Some of these genetic changes occur naturally when DNA is replicated during the process of cell division. But others are the result of environmental exposures that damage DNA.
 
        
             
        
        
        
The Hypothalamus
Hope this helped!