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Ibuprofen is synthesized by reacting ethyl 2-(4-isobutylphenyl)acetate with base, the base abstracts the acidic proton and enolate is formed which on reaction with diethyl carbonate generates diethyl 2-(4-isobutylphenyl)malonate (A). diethyl 2-(4-isobutylphenyl)malonate on treatment with Base again looses the acidic proton and forms enolate. The enolate with treatment with Methyl Iodide yields diethyl 2-(4-isobutylphenyl)-2-methylmalonate (B). diethyl 2-(4-isobutylphenyl)-2-methylmalonate on hydrolysis give Ibuprofen.
