Question

How does a large change in temperature or pH affect proteins?

Answer 1

They come apart or lose their shape. 

A biological catalyst that speed up the rate of chemical reaction in the body is known as Enzymes. Many processes in the body depend majorly on enzymes and they usually function by forming enzyme- substrate complex. However, large temperature and pH will cause the enzymes to denature this is because all enzymes are proteins and these extreme conditions will affect the bonds in their tertiary structure.

Answer 2

They come apart and lose their shape.