I know that Boston is a main port of the American Economics, so they would want it for exporting and importing goods. I would assume that Philadelphia would have a related cause.
On their northern and western frontiers, the chinese people were isolated from people in other parts of asia by the people of Mongolian, Indo-European, and Turkish ancestry resided beyond these boundaries.
Frontier :
A political and physical territory near or beyond a boundary is referred to as a frontier. A frontier can also be called a "front." The name originated in the 15th century from French and meant "borderland"—the region of a country that borders another (see also marches). In contrast to a border, which is a solid and clear-cut form of state boundary, a frontier might be imprecise or diffuse. In the 1800s, for example, the border between the Eastern United States and the Old West was a place where European American populations gradually thinned out and gave way to Native American settlements or unoccupied terrain.
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Answer:
Some of the major challenges that face the region's cities are: Inequality • Low productivity • Employment informality • Low tax collection • Insufficient investment in infrastructure • Territory and regional integration • Social insecurity, crime and violence • Environment, climate change and resilience.