The rate limiting reaction of aerobic respiration involves the phosphorylation of __________ by the enzyme _______ . The rate at
which this enzyme makes product is ___________when ATP levels rise because the molecule ___________binds to an _________ site on the enzyme and acts as a(n)_________ . When ATP levels fall ________ binds to ________of ____________. This interaction leads to an increase of cellular ___________ , so that this is a n example of a ___________ feedback loop.
The rate limiting reaction of aerobic respiration involves the phosphorylation of fructose phosphate by the enzyme phosphofructokinase. The rate at which this enzyme makes product is [increased, decreased] when ATP levels rise because the molecule ATP binds to an allosteric site on the enzyme and acts as a direct inhibitor. When ATP levels fall AMP binds to the allosteric site of phosphofructokinase. This interaction leads to an increase of cellular ATP, so that this is an example of a negative feedback loop.
Basically, what happens is that, because oxygen is really important to life, the cells go into anaerobic metabolism. Then they get depleted of the nutrients and they start dying.
