<span>Rhabdomyolysis constitutes a common cause of acute renal failure and presents paramount interest. A large variety of causes with different pathogenetic mechanisms can involve skeletal muscles resulting in rhabdomyolysis with or without acute renal failure. Crush syndrome, one of the most common causes of rhabdomyolysis presents increased clinical interest, particularly in areas often involved by earthquakes, such as Greece and Turkey. Drug abusers are another sensitive group of young patients prone to rhabdomyolysis, which attracts the clinical interest of a variety of medical specialties.
We herein review the evidence extracted from updated literature concerning the data related to pathogenetic mechanisms and pathophysiology as well as the management of this interesting syndrome.
Keywords: Rhabdomyolysis, acute renal failure, myoglobin, crush syndrome
The first case of the crush syndrome, which constitutes one of the main causes of rhabdomyolysis, was reported in Sicily in 1908, after an earthquake1,2. In 1930, in the Baltic area, an epidemic of myoglobinuria was observed due to consumption of contaminated fish. Interest in rhabdomyolysis and crash syndrome was stimulated during the World War II particularly after the bombing in London, where the victims developed acute renal failure and myoglobinuria1.
Rhabdomyolysis is a rupture (lysis) of skeletal muscles due to drugs, toxins, inherited disorders, infections, trauma and compression3. Lysis of muscle cells releases toxic intracellular components in the systemic circulation which leads to electrolyte disturbances, hypovolemia, metabolic acidocis, coagulation defects and acute renal failure due to myoglobin4.
The skeletal muscle consists of cylindrical myofibrils, which contain variant structural and contraction proteins. Actin and myosin, arranged in thin and thick filaments respectively, form the repeated functional units of contraction, the sarcomeres5. The sarcoplasmic reticulum constitutes an important cellular calcium storage. It is structurally connected to the t-tubules, that are formed by invaginations of the muscle cell plasma membrane, the sarcelemma, around every fibril (Figure 1). After the sarcelemma depolarization, the stimulation arrives, through the t-tubules junctions, at the sarcoplasmic reticulum, inducing the calcium ions release and triggering muscle contraction6.</span>
Stars are classified based on the spectral type (i.e. a means to measure the photospheric temperature and density by getting information about the ionisation state).
Under the Morgan–Keenan (MK) system using the letters O, B, A, F, G, K, and M, a sequence from the hottest (O type) to the coolest (M type) (Harvard Spectral classification based on the surface temperature of the stars). A luminosity class is added to the spectral class using Roman numerals (Yerkes Spectral classification). This is based on the width of certain absorption lines in the star's spectrum (0 or Ia+ - hypergiants, I - supergiants, II - bright giants, III - regular giants, IV - sub-giants, V - main-sequence stars, sd - sub-dwarfs, and D - white dwarfs).
Answer:
c. environmental factors such as soil pH
Explanation:
Hydrangea plants do exhibit or take on different forms of colors in reaction to environmental factors most especially, the soil pH.
Generally, Hydrangea plants will produce blue flowers if the soil pH level is below 6, while it would produce pink flowers if the pH of the soil is alkaline in nature (pH value is above 7).
The production of Hydrangea plants on the large flower garden, which produces blue flowers and pink flowers, can simply be explained to be as a result of the sensitivity to soil pH. This results in the change of the color of the flower pigment.
Answer:
The answer is 17/18
Explanation:
Please take a look at the attached picture for the explanation.
