The karyotype of a child born with Down syndrome includes a trisomy in chromosome number 21. The rest of the karyotype remains normal.
<h3>What is a karyotype?</h3>
A karyotype is a representation to indicate the chromosomes of a somatic cell in an individual.
In humans, somatic cells are diploids, thereby karyotypes will be formed by two sets of homo-logous chromosomes.
Down syndrome is caused by the presence of an additional chromosome number 21, and therefore the karyotype will exhibit three (trisomy) 21 chromosomes.
Learn more about karyotypes here:
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Answer:
Abstract
Down syndrome (DS) is associated with aberrations in genetic, morphological, biochemical and physiological characteristics. A number of genes located on human chromosome 21 (HSA21) encode proteins which are thought to be involved in numerous metabolic pathways, e.g., phosphofructokinase, cystathionine β-synthase etc. Perturbations of the metabolic pathways may lead to altered drug metabolism in DS individuals. We present a review of metabolic aberrations linked to HSA21 genes in DS. We particularly focus on drug disposition, efficacy, sensitivity and toxicity of anti-leukaemic agents including methotrexate, glucocorticoids, anthracyclines and cytarabine in DS leukaemia. The different outcomes of therapy due to differential drug response, varied drug toxicity and treatment related mortality in DS leukaemia is a subject of much research and speculation. Altered drug response in DS individuals may stem from differences in pharmacokinetics, pharmacodynamics and pharmacogenetics. Further large-cohort studies in different age groups dissecting metabolic and molecular pathways involved in drug response may increase our understanding in this regard and stipulate pharmacotherapies in DS.
Answer:
600 cm³
Explanation:
Given data:
Length of box = 25 cm
Width of box = 6 cm
Height of box = 4 cm
Volume = ?
Solution:
Volume = Length × Width × Height
Volume = 25 cm × 6 cm × 4 cm
Volume = 600 cm³
The volume of box is 600 cm³ so it can hold same volume of water.
Answer: Temperature, Wind exposure, Environmental, and light intensity. Hope this helped :)
