Question

A tricyclic antidepressant has been prescribed to a 77-year-old client whose current medication regimen includes omeprazole, captopril, calcium carbonate, alendronate, and warfarin. what assessment should the nurse prioritize when monitoring the client for drug-drug interactions?

Answer 1

Answer:

There is a need to monitor closely for bleeding and review coagulation indices when accessible.  

Explanation:

Combining warfarin with TCAs develops a threat for bleeding that should be assessed in the nursing care plan. There is no familiar association between the calcium supplements or bisphosphonates and TCAs, which would develop a threat of hypocalcemia. The TCAs do not elevate the threat of gastroesophageal reflux. The TCAs can influence blood pressure, however, this is not associated with any known drug-drug associations.  

Answer 2

Monitor the client closely for bleeding and review coagulation indices when available.

Combining TCAs with warfarin creates a risk for bleeding, which should be addressed in the nursing care plan. There is no known interaction between TCAs and calcium supplements or bisphosphonates that would create a risk for hypocalcemia. TCAs do not heighten the risk of gastroesophageal reflux. TCAs can affect blood pressure, but this is unrelated to any known drug-drug interactions.

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