:Sacrifices
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Sacrifices had a big impact on the aztec population. thousands of people were killed in order to please god
Disease
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Disease played an important part in the decline of the aztec population, Aztec caught the disease (small pox) after the arrival of the spanish. Smallpox quickly spread among the population and people had no resistance and did not know how to treat it. In many cases, everyone in a house died. With no time to bury so many people, houses were simply demolished over the bodies. it is believed that 25% of the empire was lost to the disease. But more importantly,the Aztec chain of command was in ruins. The emperor, Cuitláhuac, died of smallpox, along with many of the leaders of the army.
Spanish conquest :
The Spanish conquest of the Aztec Empire was one of the most significant in the fall of the
aztecs. it began in February 1519, and the spanish were declared victorious on August 13, 1521, when an army of Spanish led by Hernán Cortés and Xicotencatl the Younger captured Tenochtitlan, the capital of the Aztec Empire.
I dont know the other cause, but i do know that those are three of them