Question

Vasoconstriction occurs when epinephrine (adrenaline) binds to the a-adrenergic receptor on vascular smooth muscle cells. One approach to treating high blood pressures is to administer competitive inhibitors that bind to the a-adrenergic receptor. The Kd for binding of epinephrine to this receptor is ~0.6 mM. Which compounds might be a good candidate drug for high blood pressure?

Answer 1

Hello. You did not enter answer options. The response options are:

A) Compound A: Kd = 1 pM

B) Compound B: Kd = 60 pM

C) Compound C: Kd = 0.6 uM

D) Compound D: Kd = 60 uM

E) Compound e: Kd = 60 mM

Answer:

A) Compound A: Kd = 1 pM

Explanation:

Compound A for having 1pM is considered less dissociative than epinephrine, which has a dissociation constant equal to 0.6 µM. This makes compound A a good substitute because it binds to the receptor more efficiently, making it a good competitive inhibitor.