I think its A simple existence
<span>A reason for the growth of large mental institutions during the 1800s is due to poverty in that era, causing mental health problems such as depression and problems brought on by the stress and anxiety of struggling to afford to live. This increased the requirement for mental institutions.</span>
I do not know what your asking
"c. The city became a central hub for trade, which contributed to the empires growth" best describes the effect of Constantine moving the capital to Constantinople, since it was a thriving metropolis.