Long-term potentiation (LTP) is considered a cellular correlate of learning and memory. The presence of G protein-activated inwardly rectifying K(+) (GIRK) channels near excitatory synapses on dendritic spines suggests their possible involvement in synaptic plasticity. However, whether activity-dependent regulation of channels affects excitatory synaptic plasticity is unknown. In a companion article we have reported activity-dependent regulation of GIRK channel density in cultured hippocampal neurons that requires activity oF receptors (NMDAR) and protein phosphatase-1 (PP1) and takes place within 15 min. In this study, we performed whole-cell recordings of cultured hippocampal neurons and found that NMDAR activation increases basal GIRK current and GIRK channel activation mediated by adenosine A(1) receptors, but not GABA(B) receptors. Given the similar involvement of NMDARs, adenosine receptors, and PP1 in depotentiation of LTP caused by low-frequency stimulation that immediately follows LTP-inducing high-frequency stimulation, we wondered whether NMDAR-induced increase in GIRK channel surface density and current may contribute to the molecular mechanisms underlying this specific depotentiation. Remarkably, GIRK2 null mutation or GIRK channel blockade abolishes depotentiation of LTP, demonstrating that GIRK channels are critical for depotentiation, one form of excitatory synaptic plasticity.
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Answer:
(D). lungs
Explanation:
Cladograms are diagrams that show cladistic relationship between organisms of different species on the basis of their characteristics. The cladograms may include characteristics to make two organisms different from each other.
In given cladogram, characteristic that separates bony fish from amphibians is 'lungs', as lungs are absent in bony fishes, while present in amphibians.
Thus, the correct answer is option (D).
Answer:
Explanation:
Opinion on Climate Change
A poll taken in 2016 shows that 52% of Americans believe climate change to be caused by human activity, while 34% state it is caused by natural changes. Data is increasingly showing that 62% of Americans believe that the effects of global warming are happening now in 2017.
A dichotomous key helps you identify unknown specimens based on their traits because there are only two options available per trait. Selecting one from the two options (usually contrasting characteristics) from each step leads to smaller and smaller groups until the option is reduced to single and unique trait of an organism.
Considering you need to identify an organism. So, on the top of they key is animal with options: (a) with red blood cells and (b) no red blood cells. The option you will select is no red blood cells and under option b, you’re given two choices again: (a) hard bodies and (b) soft bodies. You’ll select soft bodies, then two options again are given: (a) with shell and (b) without shell. The option you’ll select would be without shell, and so on.
The options are:
A) Right Frontal Lobe
B) Right Temporal Lobe
C) Left Frontal Lobe
D) Left Parietal Lobe
E) Hypothalamus
Answer:
The correct answer is D) Left Parietal Lobe
Explanation:
Parental lobe plays an important role in combining and interpreting sensory information coming from various body parts. It process information which allows individuals to know about the position of his body parts.
The damage in the left parietal lobe will affect the right side of the body and cause numbness and impaired sensation in the right side of the body. So the individual who has damaged left parietal lobe will not able to sense any stimulus in his right hand but can still move his fingers. So the right answer is D.
