Answer:
Initially, white colonists viewed Native Americans as helpful and friendly. They welcomed the Natives into their settlements, and the colonists willingly engaged in trade with them. ... Their refusal to conform to European culture angered the colonists and hostilities soon broke out between the two groups.
The sixteenth amendment (amendment XVI)
I would say the Middle east. Specifically the region of the Holy Land (Jerusalem) in Palestine.
The main point of the crusades was the take that land into the possession of the Christians.
Hope that helps