Answer:
First Amendment: Freedom of Religion, Freedom of Press, Right to Peaceably Assemble, Right to Petition.
Second Amendment: Right to keep and bear arms.
Third Amendment: No quartering of soldiers
Fourth Amendment: Protects from unreasonable search and Seizure
Fifth Amendment: Provides protections for people accused of crimes. No citizen will be deprived of their rights without due process of the law.
It would be "germs and disease" that had the greatest impact when the Old and New Worlds met, since the Natives in the New World were not immune to the germs that the Europeans were carrying--leading thousands of Natives to be killed.