When burning, Yes.
A normal fire in a steel-frame building can soften the structure to the point of collapse.
Building laws / regulations require that all the structural steelwork is either covered in a protective coating (such as intumescent paint) or boxed in with fire-resistant plaster, so the fire can be extinguished before the building is weakened - or at least give people time to get out.
If that coating or plaster is damaged by impact or an explosion, the steel is exposed and the building can collapse relatively quickly.
(The common intumescent coatings just look like paint until exposed to fire, so the steelwork may appear to have no particular protection - but it always does).
Information:
http://www.steelconstruction.info/Fire_p...
See the images below - small buildings with steel-frame roofs after fires; you can see the amount of "sagging" and distortion on structures that have no particularly high loads.
These have burned long enough to destroy any protection, or they did not have any as the structure does not support occupied space.
http://www.champnews.com/Picture_Library...
http://thelincolnite.co.uk/wp-content/up...
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