<span>Similarities and Differences
There are many similarities and differences between the three domains. Bacteria and Archaea differ in how they gain energy. Bacteria gain energy either by being phototrophs, lithotrophs or organotrophs. One similarity between domain Archaea and domain Bacteria is that they both contain only prokaryotes while domain Eukarya only contains eukaryotes. Domain Archaea is the only domain that is sensitive to antibiotics. Another similarity between domain Bacteria and domain Eukarya is that Methionine is the first amino acid seen during protein synthesis while in domain Archaea, the first amino acid is Formylmethionine. The last major similarity between domain Archaea and domain Bacteria is that they do not contain any organelles while domain Eukarya does. A difference between all three domains is what their cell walls contain. A cell wall in domain Archaea has peptidoglycan. The organisms that have a cell wall in domain Eukarya, will have a cell wall made up of polysaccharides.</span>
Answer:
A. The chromatin near cis-regulatory sequences will be more closed and there will be less transcription.
Explanation:
In the presence of histones, the cis-regulatory sequences of DNA like promoter, enhancers etc. are not exposed. The function of the histone acetyltransferases (HATS) is to cause chromosome decondensation i.e. removal of histones from the DNA so that transcription of the DNA could occur. Histone acetyltransferases (HATS) cause acetylation of lysine amino acid of the histone proteins. Acetyl group is negatively charged so the acetylation of histone proteins leads to the removal of their positive charge which ultimately leads to the decrease in the interaction between N terminal of histones and negatively charged phosphate group of the DNA molecule. As soon as histones are removed from the DNA where cis-regulatory sequences are located, the DNA becomes accessible for transcription.
But here a drug has been added which blocks the activity of histone acetyltransferases (HATS) in cancer cells. So it is quite evident that in these cells, histones will not get removed from the cis-regulatory sequences of DNA so the DNA will be more closer or tightly packed as a result of which less transcription will occur.
The answer is Aspiration pneumonia. The low pressure in the cuff of the endotracheal tube is a risk for the aspiration pneumonia while the high cuff pressure can cause ischemia, pressure necrosis and tracheal bleeding.Hope this would be of big help.
