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introduced to individual genes, as well as genetic pathways that play important roles ... Glutaminolysis, and Fatty Acid Metabolism in Normal and Neoplastic ... As such, genetics-based therapy for .... TP53 (p53) is the most commonly mutated gene in cancer ...... Pro72Arg) that alters the amino acid sequence of the protein.
Saethre-Chotzen syndrome, Pro136His TWIST mutation, hearing loss, and ... Direct sequencing of the polymerase chain reaction-amplified coding region of the .... The present study took place at the Hospital for Rehabilitation of Craniofacial ... The sample was 19 patients with syndromic craniosynostosis (10 Apert, 5
Explanation:
They would react the same as with the vinegar and hydrogen peroxide at room temperature. They would react the same as with just the hydrogen peroxide.
Answer:
1. P120 is degraded in the 26S proteasome
2. The 26S proteasome has a major role in protein degradation and is critical for protein homeostasis
3. Cell cycle and DNA replication are cellular processes regulated by the Ras and NFkB pathways
Explanation:
The proliferation-associated nucleolar protein (p120) is a protein known to be expressed during the interphase of the cell cycle, specifically in G1 and early S phase, where any problem with DNA replication trigger a checkpoint, i.e., a molecular cascade of signaling events that suspend DNA replication until the problem is resolved. In mammalian cells, the 26S proteasome is responsible for catalyzing protein degradation of about 80% (or even more) of their proteins. The 26S proteasome acts to degrade rapidly misfolded and regulatory proteins involved in the cell cycle, thereby having a major role in protein homeostasis and in the control of cellular processes. It is for that reason that inhibitors that block 26S proteasome function have shown to be useful as therapeutic agents in diseases associated with the failure of protein degradation mechanisms (e.g., multiple myeloma). The NF-κB are highly conserved transcription factors capable of regulating different cellular processes including, among others, cellular growth, inflammatory responses and apoptosis. Moreover, the MAPK/ERK pathway is able to transduce different signals received on the cell surface to the nucleus. The MAPK/ERK pathway is activated when a singling molecule binds to a cell receptor which triggers a signaling cascade that ends when a transcription factor induces the expression of target genes, ultimately producing a response in the cell (for example, the progression through the cell cycle).
The large cell develop into mature gamete call ovum and it cytoplasm from the egg. The unequal distribution of the cytoplasm during oogenesis is necessary as the zygote that results in the cytoplasm from the egg. So the egg needs to have as much cytoplasm as possible
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