The hemoglobin holoenzyme (active enzyme) is a complex of an iron ion and 4 subunits- 2 hemoglobin alpha and two hemoglobin beta. People with sickle cell disease have mutated beta hemoglobins. The mutation is a single nucleotide exchange, that changes the 6th amino acid of protein primary struture - a Glutamic acid into Valine. This one alteration changes the tree dimentional structure of hemoglobin beta so, that it forms lond fibres that disrupt the normal circular form of the red blood cells.
Answer:
A.
Explanation:
Patient 1 has Type A blood because agglutination occurs due to reaction with anti-B. We know that A blood group has antigen A and it is anti-B means that they attack on B type of blood cells while on the other hand, B blood group has antigen B and it is anti-A means that they will attack on the A type blood cells upon mixing. So according to the chart, there is nothing happens by reaction of the blood with anti-A whereas agglutination occur by reaction with anti-B so we can say that the patient has type A blood.
