Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
Learn more about breast cancer here : brainly.com/question/6747562
#SPJ4
It affects the environment by maybe causing pollution
nfjenfkernfknrenjfkjnerkferfke feh
Answer:
d. more permeable to sodium ions.
Explanation:
The binding of Acetylcholine with the receptors at motor end plate facilitate membrane permeability to sodium ions therefore opening of voltage gated channels for sodium ions.
Sodium ions diffused into the synapse of post synaptic neuron at the neuromuscular junction.
If the stimulus is up to threshold levels; more chemical(neurotransmitter) gated sodium channels opens, and sodium ions move into the synapse to depolarize the membrane with reversal of charges to generate action potential.
The continuous binding of Acetycholine , leads to permanent opening of sodium ions,and over excitation from depolarization. Acetycholinesterase enzymes breakdown Acetycholine to choline and Acetyl Co -A. These are recycle back to Acetycholiine
The answer should be
B Both anabolic and catabolic reactions took place in the seed and tree when it was young and growing and both continue now even though the tree reached a stable mass.
The trees should be capable to do both anabolic and catabolic reaction when it is seed or when it is already a big tree. Anabolic reaction happens when the plant making bigger molecule from many smaller molecule, such as in photosynthesis. Anabolic reaction could increase the mass of the plants or be used to make food. Catabolism reaction used to extract energy from the food.
