Acceleration is defined as the rate of change in the speed of a moving body or vehicle typically.
<u>Explanation:</u>
In the branch of mechanics, the aspect of acceleration is considered to be a property of the vector. And acceleration always occurs in a specific positive direction.
The formula for determining acceleration is change in the rate of velocity over a specific time, and is therefore measured as the ratio of delta velocity by delta time unit.
The unit of acceleration is distance per time unit squared or m / second squared.
Answer:
The strengths of a focus group are:
-it gives the moderator more open ideas to work with.
-it has low cost compared to other data methods.
-it speeds up the result collection of the selected topic.
Weaknesses of focus group are:
*It takes effort to assemble the group members.
*Complex data analysis.
*No individual answers.
Explanation:
Focus groups usually involves a number of participants having an open discussion on a specific topic, set by a moderator, usually the person that comes up with the specific topic for focus. The function of a focus group is to collect data through group interactions on a selected topic.
The strengths of a focus group are:
-it gives the moderator more open ideas to work with.
-it has low cost compared to other data methods.
-it speeds up the result collection of the selected topic.
Weaknesses of focus group are:
*It takes effort to assemble the group members.
*Complex data analysis.
*No individual answers.
Answer:
Exosomes as Therapeutic Target
Given the fact that elevated exosome levels are often correlated with greater severity of different types of cancer, reducing circulating exosomes to normal levels is one of therapeutic strategies to increase treatment efficacy. There are different approaches to modulate exosome production: 1) Inhibition of exosome formation: inhibit crucial proteins involved in exosome formation pathway; 2) Inhibition of exosome release: inhibit important regulators of exosome release process, increased intracellular Ca2+, change cellular microenvironmental pH; 3) Inhibition of exosome uptake: add proteinase for surface proteins on exosomes may serve as receptors for uptake pathways. In addition to control exosomes production, removal of exosomes from the entire circulatory system might be a novel strategy for cancer treatment.
Exosomes could also be used as cancer immunotherapy becasue tumor-derived exosomes carry antigens that is a great source of specific stimulus for the immune response against tumors. Both tumor-derived and dendritic cell-derived exosomes have showed capability to stimulate tumor antigen-specific responses in experimental animal models and human clinical trials.
Exosomes as Targeted Drug Delivery Vehicles
Exosomes became one of the most common methods applied in drug delivery system because of several advantages they have. Firstly, exosomes normally have a small size 40-100 nm, which is more homogenous compared to other microvesicles. This will lead them to evade rapid clearance by the mononuclear phagocyte and enhances passage through fenestrations in the vessel wall. Secondly, due to their endogenous origin, they are less toxic for and better tolerated by the immune system. It facilitates them to avoid causing side effects that normally occur with synthetic nanoparticles. Additionally, the specific ligand or protein expressed on the exosome surface increases efficiency of cargo into the cytosol of the target cell, and therefore fewer off-target effects. Exosomes are generally found most useful as a drug delivery medium in cancer therapy, anti-inflammation and gene interference therapy such as transferring of miRNA.
There are different kinds of cargos encapsulated by exosomes, especially like siRNA or miRNA. The delivery of RNA is attracting because they are rapid degradation in cell circulation and have the limitation in passing through the membrane and in cellular uptake. Chemotherapeutics loaded into exosomes is also used for cancer therapy such as doxorubicin. In principle, there are four key components to achieve correct functionality and efficacy during exosomes drug delivery:1) Choosing the donor cell type to produce drug-carrying exosomes; 2) Using correspond methods to encapsulate the exosomes cargo; 3) Enhancing the specificity of cargo delivery by targeting peptides on the surface of the exosomes; 4) Administrating exosomes to target the area of disease.
Explanation:
https://www.creative-biostructure.com/exosome-applications-652.htm
If you applied then no it it isn’t but if u didn’t it could be....
Answer:
Cold temperature and higher pH cause the oxygen-hemoglobin saturation curve to shift high reflecting that hemoglobin releases more oxygen.
Explanation:
In higher pH i. e. neutral or alkaline and low body temperature, the hemoglobin molecule attach more oxygen to their active sites. When the temperature of the blood increases, the hemoglobin stops or reduces the binding of oxygen to their active sites and lower the saturation level. Oxygen-hemoglobin saturation level refers to the amount of oxygen binds with the hemoglobin. This saturation decreases with increase in temperature and lower pH while saturation level increases when the temperature of the body is lower and pH is high.
