<h2>GPCRs,RTKs</h2>
Explanation:
G Protein Coupled Receptors(GPCRs) are more common and found in almost all eukaryotes whereas Receptor Tyrosine Kinases(RTKs) are second largest family of receptors that relay signal from cell surface to the interior
- G protein coupled receptors(GPCRs) interacts with the ligand activated GPCR and phosphorylates its intracellular domain.This process of phosphorylation can terminate signal or desensitize receptor
- Autophosphorylation of receptor can initiate signal in case of Receptor Tyrosine Kinases(RTKs);Autophosphorylation is a feature of RTKs in which receptor dimerization activates intrinsic tyrosine kinase activity by which they phosphorylate its own tyrosine residue on cytosolic phase
- Seven transmembrane helices can be seen in case of G protein-coupled receptors(GPCRs);transmembrane protein of it consists of single polypeptide and spans the membrane 7 times
- Insulin receptor is a part of Insulin Signalling which comes under RTKs;Insulin receptor always exist in case of dimeric form
- Epinephrine receptor is an example of GPCRs;Epinephrine is an endocrine hormones produced in stress condition
- Transmembrane protein of GPCR activates G protein,activated G protein binds with effector enzyme and activate it;effector enzyme further can produce or destroy secondary messenger
Answer:
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B, circulatory and respiratory
The most likely result if a diabetic injects an overdose of insulin will be, there will be a dangerous drop in blood sugar levels. Taking too much insulin can lead to hypoglycemia, which can become serious if the insulin dose was significantly more than it should have been. It is therefore, important to take ample fast acting carbohydrate immediately and seek advice from the health team, or the out of hours service at a local hospital.