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Explanation:
Pharmacophore (pharmacology) - The molecular framework responsible for a drug's biological activity. According to IUPAC — A pharmacophore is the ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biological target structure and to trigger (or to block) its biological response.
Privileged structures are defined as molecular frameworks which are able of providing useful ligands for more than one type of receptor or enzyme target by judicious structural modifications.
1) The 1,4-dihydropyridine ring is present in many biologically important molecules that acts as an important scaffold for cardiovascular drug - a calcium antagonists and although it is technically not considered as a pharmacophore, it is considered as a privileged structure.
1,4-Dihydropyridine (DHP), belongs to the class of calcium antagonist that inhibits the influx of extracellular Ca+2 through the L-type voltage-dependent calcium channels.
A positional substitution in the 4-position is feasible in the heterocyclic ring which in turn culminates in various calcium channel antagonist activities and this heterocyclic ring is the common feature for various pharmacological activities such as anti-inflammatory activity, analgesic activity,
antihypertensive, antianginal, antitumor, antitubercular activity and antithrombotic .
Position on the heterocyclic ring binds to the L-type channel and also to N-type channel on membranes.
2.) The bioisosteres are not a suitable bioisostere for the traditional C-4 aryl or heteroaryl substitution which is necessary for calcium ion blockage thereby inhibiting it to function with the mechanism shared above.
I wish I knew but I don’t know I am so sorry but I really want to Brimley list can I please get the brain leash
While pet rabbits can survive alone without another bunny living with them, they can get very lonely and sad, as rabbits are naturally herd animals. No matter how much human attention they receive, that does not replace attention from a fellow rabbit friend.
When one rabbit is introduced to another rabbit, they may not always get along. However, they will always be very curious when they first meet, and can become close friends after bonding for a while. Keeping close supervision on bunnies when they first meet, however, is very crucial, as they could get into a fight and hurt each other.
I would say the second answers, growth. This is because we need the nutrients and vitamins from food to help us grow, and keep us healthy.
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Por naturaleza viven en los campos donde se alimentan de hierbas y pasto aunque el hombre para aprovechar al máximo a estos animales, les ha hecho establos para que el manejo de estos animales se facilite y se maximice la producción.
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