Question

A doctor sees a patient who has kidney failure, lack of motor coordination, and a poorly functioning nervous system. After testing, the doctor finds that these symptoms are all related to a chronic lack of energy in some of the patient's cells. The doctor diagnoses a metabolic disorder known as Leigh's disease.
Based on this evidence, a malfunction in what organelle is most likely responsible for Leigh's disease?

Answer 1

Mitochondria are the energy centers of the eukaryotic cells. In these organelles, ATP (the energy coin of the cell) is produced by the oxidation of pyruvate (Krebs cycle) and oxidative phosphorylation.

• Based on this information, malfunction in MITOCHONDRIA is most likely responsible for Leigh's disease.

• Cellular respiration is series of metabolic reactions by which eukaryotic cells produce energy in the form of ATP from foods and oxygen.

• Cellular respiration has three main stages: glycolysis, the Krebs cycle and oxidative phosphorylation.

• Glycolysis occurs in the cytoplasm, whereas the Krebs cycle and oxidative phosphorylation occur in the mitochondria.

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