Well there are many catastrophic scenarios that we already overcome. You should consider educating yourself about the great filter. A great filter is a hypothetical barrier that each civilization can or cannot overcome. From here on things get a little complex so I won't bore you with them. But there are experts in this theory called great filter and I'm sure they can tell you a lot about.
In the broadest sense of the term, we have modified the genes of almost everything. We used selective breeding to breed the most resistant form of crops, the largest sized chickens, and others. In recent years we have even modified them through gene splicing and other methods. Nearly everything we eat, including including "organic" foods have been changed from their original DNA structure, in fact we do not even know anything's original genetic structure because of this. Genetic modification could also include mutations. Some crops have mutated due to pollution, disease, or other effects such as climate change. Without genetic modification our world would differ from what it looks like today.
In my Biology Honors Class, they taught about gastric juice, or also known as (p H) which is formed by stomach glands, is very acidic and can seriously mess up enzyme trypsin functions. After all, enzymes are a type of catalyst that help break down food, which means that enzymes are a sort of digestive acid as well. Hope this helps!
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Dark Side- Lunar hemisphere that is not currently lit by the sun. Hope this helps!!