Explanation:
Cyclin is a family of proteins that controls the progression of a cell through the cell cycle by activating cyclin-dependent kinase (CDK) enzymes or group of enzymes required for synthesis of cell cycle.
Answer:
A sequence of three nitrogenous bases in a messenger-rna molecule is known as <em><u>Codon</u></em>
Explanation:
Codon is a triplet of three nitrogenous bases present in mRNA. It can be any three from uracil, adenine, guanine or cytosine. They are arranged in specific order and code for specific amino acids.
Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
Learn more about breast cancer here : brainly.com/question/6747562
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Answer:
c. ATP is comprised of a sugar, base, and three phosphate groups
Explanation:
ATP is the energy currency of cells and is formed during the phosphorylation of ADP. The process of ATP formation is endergonic and is often coupled with some exergonic process.
One molecule of ATP consists of one ribose sugar, an adenine base (a purine base) and three phosphate groups. Breakage of phosphoanhydride bond during hydrolysis of ATP into ADP and inorganic phosphate release a large amount of energy.
D. secondary
Two groups: primary and secondary
The primary groups has stronger and deeper relationships with its member/s than secondary groups, many of which are superficial gatherings and surface dealings.
Primary groups include:
1. Family
2. Lover
<span>3. Husband/Wife </span>
Secondary groups:
1. Colleagues
2. Classmates
3. Friends
<span>4. Acquaintance</span>
