Long-term potentiation (LTP) is considered a cellular correlate of learning and memory. The presence of G protein-activated inwardly rectifying K(+) (GIRK) channels near excitatory synapses on dendritic spines suggests their possible involvement in synaptic plasticity. However, whether activity-dependent regulation of channels affects excitatory synaptic plasticity is unknown. In a companion article we have reported activity-dependent regulation of GIRK channel density in cultured hippocampal neurons that requires activity oF receptors (NMDAR) and protein phosphatase-1 (PP1) and takes place within 15 min. In this study, we performed whole-cell recordings of cultured hippocampal neurons and found that NMDAR activation increases basal GIRK current and GIRK channel activation mediated by adenosine A(1) receptors, but not GABA(B) receptors. Given the similar involvement of NMDARs, adenosine receptors, and PP1 in depotentiation of LTP caused by low-frequency stimulation that immediately follows LTP-inducing high-frequency stimulation, we wondered whether NMDAR-induced increase in GIRK channel surface density and current may contribute to the molecular mechanisms underlying this specific depotentiation. Remarkably, GIRK2 null mutation or GIRK channel blockade abolishes depotentiation of LTP, demonstrating that GIRK channels are critical for depotentiation, one form of excitatory synaptic plasticity.
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The answer is; glycolysis
This process converts glucose molecule to pyruvate. It is an oxygen-independent pathway, unlike the Krebs cycle. Glycolysis occurs in the cell cytoplasm while the Krebs cycle (aerobic pathway) occurs in the mitochondria. In the presence of oxygen, the product of glycolysis, i.e pyruvate, is fed to the Krebs cycle. If oxygen is unavailable the pyruvate is converted to lactate.
Hydrolysis.Water can add to a material to make a new material or it can dissolve a material to change it. Have a good day
<span>siRNA guides the RISC that cleaves the target mRNA. siRNA binds to its target mRNA due to its complementarity.</span> <span>Small interfering RNA (siRNA) has a function in RNA interference, which means it causes gene silencing through repression of transcription. siRNA together with some proteins (like Argonaute) form the RISC. When siRNA recognize the target mRNA it causes degradation of mRNA and thus silencing the gene that encodes that mRNA.</span>
