The correct answer is that ferns have two part in their life cycle: Diploid phase and haploid phase
The life cycle of a fern has two parts: sporophyte stage and gametophyte stage. The gametophyte stage of ferns are haploid which releases gametes and the sporophyte stage are diploid that produces spores. This kind of life cycle is known as the "alternation of generation".
Answer:
Exosomes as Therapeutic Target
Given the fact that elevated exosome levels are often correlated with greater severity of different types of cancer, reducing circulating exosomes to normal levels is one of therapeutic strategies to increase treatment efficacy. There are different approaches to modulate exosome production: 1) Inhibition of exosome formation: inhibit crucial proteins involved in exosome formation pathway; 2) Inhibition of exosome release: inhibit important regulators of exosome release process, increased intracellular Ca2+, change cellular microenvironmental pH; 3) Inhibition of exosome uptake: add proteinase for surface proteins on exosomes may serve as receptors for uptake pathways. In addition to control exosomes production, removal of exosomes from the entire circulatory system might be a novel strategy for cancer treatment.
Exosomes could also be used as cancer immunotherapy becasue tumor-derived exosomes carry antigens that is a great source of specific stimulus for the immune response against tumors. Both tumor-derived and dendritic cell-derived exosomes have showed capability to stimulate tumor antigen-specific responses in experimental animal models and human clinical trials.
Exosomes as Targeted Drug Delivery Vehicles
Exosomes became one of the most common methods applied in drug delivery system because of several advantages they have. Firstly, exosomes normally have a small size 40-100 nm, which is more homogenous compared to other microvesicles. This will lead them to evade rapid clearance by the mononuclear phagocyte and enhances passage through fenestrations in the vessel wall. Secondly, due to their endogenous origin, they are less toxic for and better tolerated by the immune system. It facilitates them to avoid causing side effects that normally occur with synthetic nanoparticles. Additionally, the specific ligand or protein expressed on the exosome surface increases efficiency of cargo into the cytosol of the target cell, and therefore fewer off-target effects. Exosomes are generally found most useful as a drug delivery medium in cancer therapy, anti-inflammation and gene interference therapy such as transferring of miRNA.
There are different kinds of cargos encapsulated by exosomes, especially like siRNA or miRNA. The delivery of RNA is attracting because they are rapid degradation in cell circulation and have the limitation in passing through the membrane and in cellular uptake. Chemotherapeutics loaded into exosomes is also used for cancer therapy such as doxorubicin. In principle, there are four key components to achieve correct functionality and efficacy during exosomes drug delivery:1) Choosing the donor cell type to produce drug-carrying exosomes; 2) Using correspond methods to encapsulate the exosomes cargo; 3) Enhancing the specificity of cargo delivery by targeting peptides on the surface of the exosomes; 4) Administrating exosomes to target the area of disease.
Explanation:
https://www.creative-biostructure.com/exosome-applications-652.htm
According to the research, the correct option is uni-axial synovial joint. When considering the classification of joints based on the shape of the articulating bone ends, the knee functions as a type of synovial joint are called a <u>uni-axial synovial joint</u>.
<h3>What are uni-axial synovial joints?</h3>
They are synovial joints because they have cartilage and a joint capsule that allow flexion and extension movement, and it is because they move in a single plane or axis that they are considered monoaxial.
In this sense, they can be located in the humeroulnar joint located in the elbow, in the femorotibial or knee joint, allowing the rear sides of the leg to be moved away or closer, and finally in the joints that form between the phalanges of the fingers.
Therefore, we can conclude that according to the research, the correct option is uni-axial synovial joint. When considering the classification of joints based on the shape of the articulating bone ends, the knee functions as a type of synovial joint are called a <u>uni-axial synovial joint</u>.
Learn more about synovial joint here: brainly.com/question/28256806
#SPJ1
In science a hypothesis is useful only if...
1: it could be tested
2: their are two separate group
3: it's supported by evidence and facts
