Numerous antiepileptic medications, such phenytoin, have been designed to block voltage-gated sodium channels (VGSC) in neuronal membrane. In addition, multiple toxins and pharmacological modulators work by attaching to various biophysical states of the VGSC to cause their effects. Depending on how modulatory agents act, some VGSC states are stabilized or destabilized, altering the channel's biophysical properties. The first anticonvulsant to successfully treat epileptic disorders without causing undesirable side effects such as brain drowsiness was phenytoin.
Phenytoin has been indicated to block high-frequency neuronal activity potentials from the inner vestibule of the pore, as demonstrated by electrophysiological research and site-directed mutation.
Frequency and voltage both affect phenytoin binding.
There are theories that phenytoin interferes with the late sodium current that sustains depolarizations in epilepsy by blocking non-inactivated channels.
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During the summer months, the water table tends to fall, due in part to plants taking up water from the soil surface before it can reach the water table. The water table level is also influenced by human extraction of groundwater using wells; groundwater is pumped out for drinking water and to irrigate farmland.
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Answer:
Baby buffalo are typically protected by putting them i the center of the herd so that future generations can survive. Buffalo groups stay together because there is safety in a number.
D if not please answer back .
